Immunohistochemical Expression of B Cell Transcription Factors in Hodgkin’s Lymphoma and Their Use in Differential Diagnosis

Aim: Classical Hodgkin lymphoma is common, it one of the lymphomas whose differential diagnosis can be difficult. It thought that cell may originate from germinal center. Our aim in this study was to determine center transformation markers OCT-2, BOB.1, BCL-6, PAX-5, CD20 and MUM-1 Classic Lymphoma (CHL), Nodular Lymphocyte Predominant (NLPHL) Diffuse Large B-cell (DLBCL) evaluate expressions by immunohistochemical method chromogenic in-situ hybridization (ISH) EBV early RNAs (EBER).
 Material methods: 49 biopsies diagnosed with (HL), 5 NLPHL 19 DLBCL were evaluated for CD30, MUM-1, CD20, EBER positivity. SPSS 18 used statistical analysis.
 Results: 73 cases included study, 61.6% males 38.4% females. The median age patients 50 years. CHL (67.1%) most common type, mixed cellular (MSHL) subtype. There a statistically significant difference expression between (p